POMC, proopiomelanocortin, 5443

N. diseases: 873; N. variants: 39
Disease: West Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 AlteredExpression disease BEFREE These results suggest that ACTH(1-24) administrated in West syndrome may influence the expression of neurotrophic factors in astrocytes in vivo. 12438675 2002
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 AlteredExpression disease BEFREE We conducted a retrospective, chart review of IS cases that were treated with biologic short-acting ACTH and followed up for at least 6 months at a single center in China between June 2010 and June 2016. 28421469 2017
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human Cardiac vagal activation by adrenocorticotropic hormone treatment in infants with West syndrome. 17287597 2007
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human Images in cardiology. Enlargement of cardiac rhabdomyoma and myocardial ischaemia during corticotropin treatment for infantile spasm. 10908253 2000
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human Given the very poor prognosis of infantile spasms especially in such conditions as cerebral palsy, the combination of ACTH and vigabatrin appears to be an interesting therapy advance with very few side effects. 8980841 1997
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human A fatal incident during combined anticonvulsive therapy with ACTH and Dexamethason prompted us to reevaluate our treatment results in 19 children suffering from infantile spasms. 2983143 1985
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human In spite of conflicting views as to the long-term effects of ACTH, prompt treatment seems to be mandatory, at least in cryptogenic cases of infantile spasms. 6259007 1981
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human Hypertrophic cardiomyopathy during corticotropin therapy for infantile spasms. A clinical and echocardiographic study. 8381257 1993
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human Hormonal background of the hypertension and fluid derangements associated with adrenocorticotrophic hormone treatment of infants. 2551692 1989
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human Pediatricians should be aware that cardiac dysfunction could be associated with ACTH therapy for West syndrome. 19039989 2008
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human The seizures occurred following the suppression of infantile spasms with adrenocorticotropic hormone therapy and disappeared following the cessation of clonazepam administration. 1656808 1991
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human The CSF levels of beta-EP and ACTH were significantly lower in patients with IS than those in the controls. 11341487 2001
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human [Treatment of infantile spasms with long-term low dose ACTH]. 1327015 1992
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human A one-year-old boy presented with hypercalciuria and nephrolithiasis following a course of ACTH therapy for infantile spasms. 1324751 1992
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human Vigabatrin and ACTH showed no significant difference in the initial treatment of infantile spasms. 20078871 2010
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human ACTH therapy in infantile spasms: side effects. 6254450 1980
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human Renal and pancreatic calcification during treatment of infantile spasms with ACTH. 6143199 1984
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human [Lethal side effects from ACTH-therapy in infantile spasm (author's transl)]. 6107850 1980
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human [Cardiac hypertrophy associated with subaortic obstruction induced by adrenocorticotropic hormone treatment]. 1965992 1990
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human [Secondary myocardial hypertrophy in newborn infants and infants without congenital heart defect]. 2853496 1988
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human [Hypertrophic myocardiopathy during the corticotropin treatment of infantile spasms]. 8928979 1996
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Therapeutic disease CTD_human ACTH-induced seizures in an infant with West syndrome. 2554740 1989
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Biomarker disease CTD_human [Treatment of infantile spasms with long-term low dose ACTH]. 1327015 1992
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Biomarker disease BEFREE Adrenocorticotropic hormone (ACTH) therapy is the first-line therapy for infantile spasms, and is effective for many other intractable epilepsies. 25149137 2015
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.400 Biomarker disease BEFREE Comparison of efficacies of zonisamide versus adrenocorticotropic hormone was as following: the cessation of epileptic spasms (27% vs. 40%, p = 0.70), resolution of hypsarrhythmia at 14 days (20% vs. 33%, p = 0.68) and resolution of hypsarrhythmia at 6 weeks (36% vs. 71%, p = 0.14). 30293931 2019